The number of new coronavirus cases around the world fell 21 percent in the last week, marking the third consecutive week that COVID-19 cases have dropped, reported the World Health Organization this week. Deaths fell eight percent, the first time they have fallen since early January.

However, while the declining numbers were certainly welcome news, the UN health agency’s weekly pandemic report indicated that there were still more than 12 million new coronavirus infections last week and about 67,000 new COVID-19 deaths worldwide.

The Western Pacific was the only region that saw an increase in COVID-19 cases, with a 29% jump, while the number of infections elsewhere dropped significantly. The number of new deaths also rose in the Western Pacific and Africa while falling everywhere else. The highest number of new COVID-19 cases were seen in Russia, Germany, Brazil, the US, and South Korea.

WHO said omicron remains the overwhelmingly dominant variant worldwide, accounting for more than 99% of sequences shared with the world’s biggest virus database. It said delta was the only other variant of significance, which comprised fewer than 1% of shared sequences.

WHO also reported that available vaccine evidence shows that “booster vaccination substantially improves (vaccine effectiveness),” against the omicron variant, but said more details are still needed on how long such protection lasts.

The agency had previously said there was no proof that boosters were necessary for healthy people and pleaded with rich countries not to offer third doses to their people before sharing them with poorer countries.

Health officials have noted that omicron causes milder disease than previous COVID-19 variants and in countries with high vaccination rates, omicron has spread widely but COVID-19 hospitalization and death rates have not increased substantially.

Scientists, however, warn that it’s still possible that more transmissible and deadly variants of COVID-19 could still emerge if the virus is allowed to spread uncontrolled.

WHO’s Europe chief Dr. Hans Kluge says the region is now entering a “plausible endgame” for the virus and said there is now a “singular opportunity” for authorities to end the acute phase of the pandemic.

This week, Britain announced it would scrap all remaining COVID-19 restrictions, including the requirement for people with the illness to self-isolate, even as Prime Minister Boris Johnson acknowledged there could be future deadly variants of the virus. Earlier this month, Sweden abandoned wide-scale testing for COVID-19 even in people with symptoms, saying that testing costs and the expense of its pandemic restrictions were “no longer justifiable.”

Hong Kong’s leader, meanwhile, announced Tuesday that the city will test its entire population of 7.5 million people for COVID-19 three times in March as it grapples with its worst outbreak yet, driven by the highly contagious omicron variant.

In the US, total confirmed cases reported Saturday barely exceeded 100,000, a sharp downturn from around 800,850 five weeks ago on Jan. 16, according to Johns Hopkins University data. In New York, the number of cases went down by more than 50% over the last two weeks.

“I think what’s influencing the decline, of course, is that omicron is starting to run out of people to infect,” said Dr. Thomas Russo, professor and infectious disease chief at the University of Buffalo’s Jacobs School of Medicine and Biomedical Sciences.

COVID-19 hospitalizations were down from a national seven-day average of 146,534 on Jan. 20 to 80,185 the week ending in Feb 13, according to the Centers for Disease Control and Prevention.

Public health experts say they are feeling hopeful that more declines are ahead and that the country is shifting from being in a pandemic to an ‘endemic’ that is more consistent and predictable. However, many expressed concern that vaccine uptick in the US has still been below expectations, concerns that are exacerbated by the lifting of COVID-19 restrictions.

In Canada, despite haphazard counting measures across the country, the federal government reported just over 5,200 cases and 100 deaths on Wednesday. However, chief public health officer Dr. Theresa Tam said last week that Canada has passed its omicron peak and may be entering an endemic phase. But she cautioned that that the lifting of prevention measures in various provinces could lead to another surge.